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Five anti-inflammatory mechanisms that matter for endometriosis The anti-inflammatory effects of GLP-1 agonists are not vague or theoretical

[iii] Pickart, L

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137 (12), 25702577 (2017) L

Although small amounts of NAPQI, which is metabolized from APAP by hepatic cytochrome P450 2E1 (CYP2E1), can be detoxified by glutathione (GSH) conjugation, excessive formation of NAPQI after APAP overdose rapidly depletes hepatic GSH and thus causes the formation of protein adducts, particularly in mitochondrial proteins 3,4