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Additionally, this subtype has been associated with enhanced mitochondrial function [20, 22]

Access this article Similar content being viewed by others Abbreviations AITC: Allyl ITC BITC: Benzyl ITC CDK: Cyclin-dependent kinase Cox-2: Cyclooxygenase 2 CYP: Cytochrome P450 ESP: Epithiospecifier GSH: Glutathione GST: Glutathione S-transferase HO-1: Heme oxygenase 1 iNOS: Inducible nitric oxide synthase ITC: Isothiocyanate Keap1: Kelch-like ECH-associated protein 1 MRP: Multidrug resistance associated protein NAC: N -acetylcysteine NQO1: NAD(P)H:Quinone Oxidoreductase Nrf2: Nuclear factor erythroid-derived 2-like 2 PEITC: Phenylethyl ITC ROS: Reactive oxygen species SF: Sulforaphane TR1: Thioredoxin reductase 1 References Ambrosone CB, McCann SE, Freudenheim JL et al (2004) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype

10.1161/CIRCULATIONAHA.117.031264 5

A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease

The results are often cumulative, and regular infusions may be needed to sustain the benefits over time

Melatonin is likely the limiting factor