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The potentiation was associated with the phosphorylation of Ser1303 in GluN2B subunits of NMDAR, which increased the receptors conductance and was absent in 5-HT 2A KO mice (Barre et al., 2016)

This indicated juglone might not be competing with glutathione for the binding site, in agreement with the kinetic studies (Video S1)

CJC-1295s human evidence stops at raising GH and IGF-1 a mechanism result, not a demonstrated clinical benefit

USA 115 , E11623E11632 (2018)

doi: 10.1016/j.nbd.2023.106396 34 HlebokazovF.DakukinaT.PotapnevM.KosmachevaS.MorozL.MisiukN.et al