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A phylogenetic analysis based on full-length protein sequences revealed that the SmGSTs can be arranged into 2 main clades: Clade I and Clade II (Figure 1A)

Tang et al., 2022)

Thus, it should be inferred that deterioration and inefficiency of these key methyl group metabolic pathways may contribute to DNA methylation aberrations as we observed in dedifferentiation processes, aging, and cancer initiation and justifiably assume their causal role

Interestingly, all TARDBP family fibroblasts showed an increased reliance on glutamine, suggesting an anaplerotic use of Krebs cycle

Proteomics 75, 40744090

JEOL, Tokyo, Japan)