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To further compare GSH synthetic capacities of different pathways, GSH1 gene of engineered strain W303-1b/F was deleted to eliminate synthesis of GSH by endogenous enzymes

This would be particularly helpful for approaches aimed to target eNOSs essential interacting partners and numerous transcriptional factors that are abundant also in other tissues

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Batch culture of the engineered strain W303-1b/FGP for GSH production The batch fermentation was operated in a 10-L fermentor (China Beauty)

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(2009) cMyc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism, Nature , 458 , 762-765, doi: Altman, B