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Haematological symptoms are among the earliest manifestations and include: Fatigue and generalised weakness Pallor due to anaemia (which may be macrocytic, though this is not universal) Shortness of breath on exertion Palpitations or tachycardia Neurological symptoms can be particularly concerning and may include: Peripheral neuropathy with tingling, numbness, or burning sensations in the hands and feet (paraesthesia) Loss of vibration sense and proprioception Ataxia and difficulty with balance or coordination Cognitive impairment, including memory problems and difficulty concentrating Mood disturbances, including depression and irritability In patients with diabetes, distinguishing between diabetic neuropathy and B12 deficiency-related neuropathy can be challenging, as both conditions may coexist

Editorial Advisory Board Member, Harvard Health Publishing Teresa Fung, ScD, RD Contributor

Ecotoxicol Environ Saf 6, 32835

Inflammasomes are multiprotein complexes localized in the cytoplasm of the cell that play a crucial role in innate immunity, which are assembled, activated, and mediated the occurrence of inflammation [11, 12]

doi: 10.3389/fneur.2023.1103416 114 QuY.YanM.ZhangQ

Amyloid beta fragments responsible for the pathological conditions in AD AD patients have insoluble peptides known as amyloid beta due to the digestion of APP by alpha- and gamma-secretases, leading to amyloid beta plaques and cell degeneration