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The main enzymes involved in enzymatic reactions are uncoupled endothelial nitric oxide synthase (eNOS), NADPH oxidase (NOX), xanthine oxidase (XO), arachidonic acid (ARA), peroxidase, and metabolic enzymes such the cytochrome P450 system, cyclooxygenase, and lipoxygenase

In the future, it is necessary to consider the integrating variables of hostmicrobiota interactions, and combine spatial metabolomics with single-cell transcriptomics to precisely locate polysaccharides targets in the intestinal tract, and achieve cellular-resolution mechanistic insights, thus providing a scientific foundation for their application within clinical settings and drug development

Mol Interv 7:31324 Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD (2008) Molecular mechanisms and clinical implications of reversible protein S -glutathionylation

In particular, there is a need for studies that examine the interactions between different interventions, such as the combined effects of exercise, diet, and pharmaceutical agents like metformin or rapamycin, to provide a more holistic understanding of how these factors work together to promote longevity

Figure 8 illustrates the fate of dietary polyphenols within the human digestive system, beginning with their natural occurrence in fruits and vegetables as aglycones, glycosides, or bound forms