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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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The mechanisms that may contribute to the induction of oxidative damage in diabetic patients include hyperglycemia-induced glucose auto-oxidation, non-enzymatic glycation of proteins and lipids, increased sorbitol pathway activity, oxidation of AGEs, and formation of prostaglandin H2 (PGH2) [311]

This typically resolves as your body adjusts

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