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The second approach relied on chronic continuous exposure to clinically relevant drug concentrations for 721 days

Owens KH, Medlicott NJ, Zacharias M, WI M, Buckley NA, Reith DM

In the brain, mHTT causes neuronal dysfunction and death through various mechanisms including formation of abnormal protein aggregates and disruption of proteostasis, and resulting impairments in synaptic, mitochondrial, and axonal transport functions