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Chronic constipation patients have reduced EC cell density, decreased 5-HT synthesis, and significantly lowered colonic tissue 5-HT concentrations (Coates et al., 2004)

doi: 10.1001/jama.2020.1585 201 ZuoYYalavarthiSShiHGockmanKZuoMMadisonJAet al

This therapy is particularly beneficial for individuals with nutrient deficiencies or individuals who may be recovering from an illness

First, melatonin appears most useful where oxidative load is high (e.g., PCOS, diminished ovarian reserve, repeat-poor response), aiming to improve oocyte/embryo competence rather than to replace first-line ovulation-induction strategies