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Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I

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Inflammatory mediators not only damage testicular architecture by impairing the blood-testis barrier [13] but also disrupt the function of Leydig cells, which are responsible for testosterone synthesis [12, 27]

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7-10 Centrally, persistent inward currents mediated by GABAergic transmitters at the spinal level can amplify incoming sensory input and lead to the propagation and amplification of cramp potentials

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The compound was originally developed by Ipsen but was licensed to Rhythm Pharmaceuticals in 2010 (67, 68)

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