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Additionally, by reducing the expression of Smad1 and Smad5, Smurf1 inhibits the TGF-/BMP signaling pathway, promotes cell proliferation, and is crucial for the development of renal tissue[108]

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doi: 10.3389/FIMMU.2020.595835 56 RajabIMHartPCPotempaLA

Assessment of CD206 + CD68 + macrophages (a putative tissue-repair cell) revealed reduced numbers in biopsies from patients with IBD [5], but it was not determined if this was due to lack of recruitment, conversion to another phenotype (or loss of CD206 and/or CD68 expression), or increased in situ cell death

10.1016/j.jaci.2010.01.056 91 KangX

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