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This response is partially mediated by CGRP and/or CSD, and involves oxidative stress, mitochondrial dysfunction, the assembly of NLRP3 inflammasomes, activation of microglia, and the reactivity of astrocytes

Infusions are safe when performed under medical supervision

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Gene expression remodeling: Research by Pickart and Margolina identified over 4,000 human genes regulated by GHK-Cu, including many involved in tissue repair and immune modulation

DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request