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doi: 10.1056/NEJMp1416014

Valeyre, D

In addition to direct modulators, phosphorylation inhibitors, which target tau aggregation by reducing the hyperphosphorylation that correlates with aggregation, have been tested as potential therapeutic agents, yet to date, none of the attempts have resulted in approved therapy

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This association persisted for at least 48 h post transformation from miracidia to sporocyst, suggesting the developing larvae consistently share at least certain surface proteins during the first 48 h of infection, during which, they are most likely to be targeted by the snail immune response (28)