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In insulin signaling, zinc activates the insulin-dependent tyrosine kinase pathway and promotes the phosphorylation of PI3K and AKT, fine-tuning the insulin receptor signaling cascade to improve both insulin secretion and peripheral sensitivity (32)

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Moreover, about one-third of school-age children (6-12 years old) worldwide (241 million children in 2011) have insufficient iodine intake (5, 7)