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attenuation of ROS generation [144], degradation of inflammatory chemokines [71] or via induction of the NET-suppressive cytokine interleukin-10 [145])

[18] When all remaining reduced glutathione is consumed, enzymes and other proteins (including hemoglobin) are subsequently damaged by the oxidants, leading to cross-bonding and protein deposition in the red cell membranes

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To address this gap, analyzing key drivers of MDVs could elucidate how their biogenesis is upregulated in response to altered energy metabolic conditions, which merits further investigation

doi: 10.1111/j.1472-765X.2010.02900.x 187 JohnsonM