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Thats one of many examples where you would have to do the right testing because it makes the difference between one, like two opposite actions where, depending on whether youre right or wrong, the action could either be the solution or make the problem dramatically worse

Among them, ENSRNOG00000031607 gene expression was most significantly downregulated, whereas ENSRNOG00000065367 gene expression was most significantly upregulated, and their log2 FC values were 7.29 and 6.89, respectively

doi.org/10.1093/advances/nmy057 Moslemi MK, Tavanbakhsh S

In the fed state, elevated bile acid levels activate FXR, which translocates to the nucleus and binds to the promoters of ATGs such as ATG7, ULK1 , and TFEB