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10.1182/blood.v92.4.1191.416k15_1191_1198 31 LanganR

Preclinical investigations in aged animal models have reported that NNMT inhibition may: Influence activation of muscle-resident stem cells following injury Alter myofiber cross-sectional area and contractile properties Interact with NAD-dependent mechanisms implicated in mitochondrial quality and tissue resilience These findings support the use of 5-Amino-1MQ as a research tool for studying muscle regeneration, sarcopenia models, and age-associated changes in muscle physiology

B., Van der Gaag, M., Van den Berge, M., Duivenvoorden, H

Novel defects in collagen XII and VI expand the mixed myopathy/EhlersDanlos syndrome spectrum and lead to variant-specific alterations in the extracellular matrix

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IGF-1 LR3 in Stem Cell Self-Renewal Research Research has established that IGF-1 receptor signalling is necessary for human embryonic stem cell self-renewal, and that IGF-1 LR3 can substitute for native IGF-1 in stem cell cultures with increased potency and stability requiring lower concentrations for equivalent or superior biological effects compared to unmodified IGF-1