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What it depletes: Vitamin B12 (see acid-reflux drugs, above, for more info) Do you need a supplement

10.1016/j.phymed.2022.154457 193 SundaramoorthyA.ShanmugamN

[PubMed] Petriello MC, Brandon JA, Hoffman J, Wang C, Tripathi H, Abdel-Latif A, Ye X, Li X, Yang L, Lee E, Soman S, Barney J, Wahlang B, Hennig B, Morris AJ (2018) Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice

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This is often done because standard glutathione is notoriously difficult for the body to absorb