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Introduction Substance use disorders (SUD) are chronically relapsing conditions characterized by compulsive substance-seeking, lack of control in restricting intake, and the development of negative emotions during withdrawal (1)

The glutathione/metallothionein system challenges the design of efficient O2 -activating copper complexes

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These studies confirmed the formation of mixed oligomers of the two enzymes and provided information for modeling the architecture of their complex

AUD alcohol use disorders BHB -hydroxybutyric CPP conditioned place preference DA dopamine DUD drug use disorders GABA -aminobutyric acid IL interleukin KD ketogenic diet MOR mu-opioid receptor NAc nucleus accumbens NLRP3 nucleotide-binding domain-like receptor protein 3 ROS reactive oxygen species SUD substance use disorders TNF tumor necrosis factor Abbreviations References 1