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In addition, RAM contains particular cell types, as well as extracellular matrix molecules which are vitally distinct from those found in healthy sites, including inflammatory factors, reactive oxygen and nitrogen species (RONS), immunogenic proteins, and oxygen [8, 9]

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showed that in cultured rat ventricular myocytes, trimetazidines beneficial effects were only observed when cells were undergoing hypoxia and not during normoxia, highlighting trimetazidine as a metabolic regulator that would not increase mitochondrial function in healthy states [123]

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