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(10) In cell cultures of fibroblasts, which are the main type of cell producing collagen in tissues, including ligaments, the peptide appeared to markedly support fibroblast outgrowth, migration, and spreading

1.5 Empirical Therapy for Febrile Neutropenic Patients CIPRO IV is indicated in adult patients for the treatment of febrile neutropenia in combination with piperacillin sodium [see Clinical Studies (14.1)]

1.2 ENS plays a pivotal role in the pathogenesis and progression of colitis The ENS, composed of a dense network of enteric neurons and enteric glial cells (EGCs), functions as a dynamic sensor-effector interface capable of detecting and responding to pathophysiological perturbations within the intestinal microenvironment ( 2+ /Zn 2+ -binding protein S100, which is strongly implicated in the initiation and perpetuation of intestinal inflammation in the human colon ( However, recent studies have challenged the presumed specificity of S100 expression in glial cells, revealing its low-level expression in certain immune cells as well ( EGCs express a diverse repertoire of purinergic and adenosine receptors, including P2Y1 ( Figure 1 )

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Price AJ, Travis RC, Appleby PN, Albanes D, Barricarte Gurrea A, Bjrge T, et al