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Both epidermis-specific Mll4- knockout mice and Alox12b loss-of-function mutant mice exhibited epidermal hyperproliferation, scaling, and other cutaneous manifestations similar to ichthyosis, as well as a deficiency of ALOX12b expression in the epidermis of both mice

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The targeted delivery of neuroprotective agents across the BBB is mainly attributed to their increased drug-loading capacity and controlled release mechanisms

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