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For example, the interaction between ApoE and TREM2, another major risk factor for sporadic AD, has been reported to facilitate the uptake of A by microglia, and AD-linked mutations in TREM2 impair the binding affinity of TREM2 for ApoE leading to A accumulation in the brain (Yeh et al., 2016)

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Formation of ROS via photo-oxidation affects the rods more severely since these cells detect dim light to provide night vision and are more vulnerable to damage induced by daylight 23

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia

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