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This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation

Makimura H, Feldpausch MN, Rope AM, Hemphill LC, Torriani M, Lee H, et al

Unlike synthetic B12 forms, methylcobalamin is ready for the body to use immediately and does not require conversion

S2) or phylogenetic diversity as measured by Faiths formula applied to the whole phylogenetic tree (Supplementary Fig

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Methylcobalamin is the superior form of B12 that your body actually wants