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4E) and DMF treatment increases both NRF2 association and active histone codes at the CBS gene ARE motif (Fig

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These nuances do not negate the Complex I paradigm but qualify it as predominant rather than exclusive.Metabolic reprogramming: Prolonged ETC-I inhibition stimulates glycolytic metabolism as a compensatory mechanism for ATP production, resulting in lactate accumulation (106)a phenomenon particularly detrimental to patients with renal impairment

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