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For instance, in vivo isotopic labelling studies, in lung cancer patients and animal models, indicated minimal utilization of glutamine in the TCA cycle with glucose and lactate identified as the main contributors to TCA intermediates 9,10

doi: 10.1146/annurev-immunol-032712-100001 112 GaoLJiangYWangYQuXZLiLLouXQet al

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And while increased Thymosin Beta-4 expression is uniformly seen in the joint fluid of rheumatoid arthritis patients, it is uncertain whether this outcome is beneficial or harmful