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Due to neuronal dependency on alcohol for regular activity in individuals with AUD, cessation of alcohol consumption often leads to withdrawal (Littleton, 1998)

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Its N-terminal acylation blocks dipeptidyl peptidase IV (DPP-IV) cleavage, extending plasma half-life relative to native GHRH while preserving full GHRH-receptor agonism at the pituitary somatotroph

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