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Studies demonstrate that silybin can effectively mitigate neuroinflammation by reducing the expression of pro-inflammatory cytokines such as IL-1, TNF-, and IFN-, and by suppressing the activation of the STING-IRF3-IFN- pathway ( 3.3 Effect on subarachnoid hemorrhage Research has found that silybin can improve neuronal injury and short-term neurological function in mice with subarachnoid hemorrhage, reducing inflammatory damage and neuronal apoptosis

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3.2.2 Chemosensory proteins CSPs are a family of small soluble proteins similar to OBPs that help to trap and transport odorants suspended in the lymph to the ORs and Orco complexes

Because NO can dissolve in both water and lipids, it can easily diffuse through the cytoplasm and plasma membrane (Phaniendra et al., 2015)

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