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3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

Karimian Pour N, Piquette-Miller M

Gridelli C, Ardizzoni A, Ciardiello F, Hanna N, Heymach JV , Perrone F, Rosell R, Shepherd FA, Thatcher N, Vansteenkiste J, De Petris L, Di Maio M, De Marinis F

PBMC isolation Peripheral blood was collected in EDTA-containing tubes and PBMCs were isolated using SepMate-50 tubes according to the manufacturers protocol (STEMCELL Technologies)

Within this interface, Phe288, Phe306, Phe311, Asp345, and Gln349 from one subunit form an intricate interacting network with Arg308 and Gln312 from the subunit of an adjacent tetramer (Fig