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To boost pegtibatinase stability and minimize unwanted protein aggregation, a cysteine-to-serine substitution at position 15 is introduced to prevent the formation of interdimer disulfide bonds

This does not imply universal conclusions, but it emphasises the importance of professional judgement in risk profiles or in people with pathologies

In summary, although current studies on ferroptosis in cerebral ischemia have identified key biological processes such as lipid peroxidation and iron metabolism imbalance, two central challenges remain unresolved

Savagner, P

Montesarchio, V

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