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developed a lipid nanoparticle delivery system for melphalan and miRNA-181a, resulting in superior transfection efficiency and reduced toxicity in Y79 cells and RB heterotopic transplant rat models [316] ( Fig

2AC) [28]

Transcriptional regulation Comparison of mouse, rat, and human gene sequences indicates a conservation of the sequence and overall structure of the GPx-1 gene, with the protein coding region contained within two exons and the Sec codon in the first exon (Fig