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Adiponectin, for instance, does not affect circadian clock gene expression in some peripheral tissues, but its knockout alters the circadian rhythm of glucose and lipid metabolism 115

If the level of oxidized glutathione begins to climb, it is often a sign that the body is under significant physiological stress

The specific mechanism by which enzymatic reactions cause lipid peroxidation is that Acyl-CoA synthetase long-chain family member 4 (ACSL4) and Lysophosphatidylcholine acyltransferase-3 (LPCAT3) first activate polyunsaturated fatty acids (PUFAs) to bind to lipids in the cell membrane (e.g., phosphatidylethanolamine PE), forming the PUFA-PE complex (Su et al., 2019)

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