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10.1016/j.biopha.2021.111676 26 HajamY

51 In the substantia nigra pars compacta of affected patients, iron was shown to accumulate in glia cells and dopaminergic neurons, with the level of iron correlated with disease severity

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It is still not known whether donor astrocytes could be negatively influenced by the toxic host environment and by activation signals from degenerating motor neurons, and if healthy transplanted cells can turn into aberrant astrocytes

To the best of our knowledge, there are only few studies that report the efficacy of CEF pretreatment in reducing nicotine-seeking behavior, preference in CPP, and withdrawal manifestations

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