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It is estimated that a typical mammalian cell experiences 10,000 to 100,000 endogenous DNA lesions per day (averaging roughly 70,000), most of which are SSBs [26]

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Methods: Patients eligible for PEDFIC 1 (NCT03566238) and PEDFIC 2 (NCT03659916) had elevated serum bile acids and significant pruritus at screening