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Motif analysis revealed that genes within the same subfamily exhibited similar motif compositions, indicating conserved motif types and distributions among closely related genes

G., Gannon, J., Self, M

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Conclusions and future perspectives Therapeutic strategies targeting the ERS-death axis through precise modulation of UPR core pathways (PERK, IRE1, ATF6) and downstream molecules (CHOP, GRP78, XBP1, etc.) have demonstrated significant antitumor potential in preclinical studies

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were the first to show that oral administration of Lactobacillus engineered to express full-length GLP-1 (137) could induce intestinal epithelial cells to transdifferentiate into insulin-producing cells, restoring up to 33% of normal insulin secretory activity