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Collagen fibers are thicker and coarser in the inner dermal layer than in the outer layer, with thinner and more tenuous collagen fibers (68)

A novel PDX-based 2-stage screening platform can identify active drug combinations against KRAS-mutated colorectal cancer

Front Pharmacol 13:1003812

doi: 10.1016/j.immuni.2017.02.013 263 WatanabeD.UchiyamaK.HanaokaK

There is a resulting reduction of Th2 responses and mast cell degranulation, and hence allergic disease pathology and symptomology

Methodology Plasma sample collection To minimise the effect of environmental factors impacting overall metabolomics among individuals, all patients were chosen from the Northern Sweden cohort