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While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

In a study using the DBA/2J mouse model of elevated intraocular pressure and secondary glaucoma, mice fed the KD for 8 weeks showed significantly increased retinal ganglion cell (RGC) survival and axon number compared to mice fed the control diet (14)

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10.1016/0300-483X(88)90010-8 58 FreyW

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