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While its role in cancer is intricate, Beclin-1 is crucial clinically, as its levels can impact how cancer patients respond to chemotherapy

J.SunC.ZhangT

Moreover, it promotes degeneration of epithelial cells of the proximal convoluted tubule and tubular cylinders, enhances focal mineralization, damages podocytes of the Bowman's capsule, increases serum levels of urea and creatinine, and brings about histological changes in kidney tubules ( Figure 4 ) [77,84]