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Topical gels, especially those using advanced delivery systems (like the Avant Labs carrier), bypass the liver and absorb through the skin, delivering more active ingredients directly into the bloodstream or localized tissue

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This discovery provides crucial theoretical underpinnings for employing PF in clinical settings to alleviate DPN-associated pain

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To assess the necessity of DP for localization of Ect2 at IDs, NRVCMs were treated with adenovirus harboring either control (nontargeting) or DP KD shRNA constructs followed by PLA analysis