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housing, detox, addiction medicine clinic, family doctor services, safe injection facilities) Discuss and offer naloxone kits, clean injection supplies Counsel around high risk of accidental overdose given withdrawal and/or decrease in tolerance Pitfall: Sending an opioid patient directly to a detoxification center who is not psychologically ready to quit opioids can have devastating consequences

B.FigueroaE.LetelierP.et al (2017)

doi: 10.1038/s41598-021-98317-w 161 MagyariM

The user gets high energy, both the physical and psychological abilities enhance to a great extent

Noble W, Planel E, Zehr C et al (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

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