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Site 1 is a hydrophobic pocket buried among the main and side chains of L173, K177, L285, I289, V293, L315, I318, and Y29

10.3389/fimmu.2015.00636 16

But some oral drugs can be greatly affected by very small changes in their amount

I see patients all the time that have been getting Botox with me and then they have to get a round sometimes with a different provider for some reason