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doi: 10.1016/j.neo.2022.100874

On the other hand, ROS induce the binding of Src homology 2 domain-containing phosphatase 1 (SHP1) to c-Src and the oxidation of c-Src and SHP-1, which lead to SHP-1 inactivation and activation of c-Src via phosphorylation of Tyr416, contributing to osteoclast survival and increasing bone loss (226)

[Abstract] Adv Sci (Weinh)

m is generated by the proton-pumping activity of ETC Complexes I, III, and IV and functions as a crucial energy source for many transporters within the inner mitochondrial membrane