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Esposito A, Criscitiello C, Gelao L, Pravettoni G, Locatelli M, Minchella I, et al

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Subsequent secondary-source reviews have proposed candidate interactions modulation of GABAergic and glutamatergic tone, possible NMDA-receptor involvement, peripheral 1-adrenergic effects but these have not been replicated in primary studies that establish direct binding or saturable transduction at a defined receptor