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KEY POINTS Harmful Reactive Oxygen Species (ROS), including hydrogen peroxide, accumulate during cell respiration

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Second line defense antioxidants This group of antioxidants is often referred to as scavenging antioxidants

Microglial ablation during the symptomatic phase of EAE has been shown to reduce CNS inflammation and promote recovery (Nissen et al., 2018), but impeding microglial function may also limit remyelination (Stangel et al., 2017

Together, those results show that understanding the interaction between microglia and astrocytes in demyelination and, more specifically, in the pathogenesis of MS, should provide key clues for new DMTs, that are certainly missed by looking at those subpopulation of glial cells individually