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For example, berberine, a classic isoquinoline alkaloid, effectively inhibited mitochondrial ROS generation and mitochondrial antiviral signaling protein activation in influenza-stimulated in influenza-stimulated mouse macrophage cell line J774A.1 (J774A.1), thereby blocking NLRP3 assembly and pyroptosis within 24 h at 4.2 M(Zhao et al., 2025)