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Using hydrogendeuterium exchange, structural modeling and site-directed mutagenesis, we identified the formation of an intricate complex with FAT10 that activates NUB1 for docking to the 26S proteasome, and our cryo-EM studies visualized the highly dynamic NUB1 complex bound to the proteasomal Rpn1 subunit during FAT10 delivery and the early stages of ATP-dependent degradation

In this study, our results observed a negative association between vitamin B2 intake and ALP levels, suggesting that vitamin B2 may improve bone health via reducing bone turnover rates

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J., Kerr, G., Meinzer, M

Therefore, the net binding free energy was defined using the total enthalpy in the system and expressed as a summation of total molecular mechanical energy (E MM ) and solvation free energy (G Sol )

(2023) captures the limited array of treatment options available for VRE blood stream infections, the complexities of dosing regimens and promise of therapeutic drug monitoring (TDM) for improving clinical outcomes [115]