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doi: 10.1038/s41598-020-62755-9 67 KostrzewaR

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Additionally, Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) phosphorylates RyR2, increasing its open state probability and leading to SR Ca 2+ leak through RyR2 [Figure 1] [31,32]

The importance of this mechanism in regulating GPx-1 expression under oxidative stress has not been established

These factors promote the transcription of the MMP-13 gene by activating the MAPK and NF-B signaling pathways

Collectively, these effects may contribute to weight loss post-surgery in obese patients, suggesting the functional use of tripeptides for weight loss [182]