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Only mild detox symptoms may occur initially

NOX4 is the primary producer of ROS in cells

PARP-1 serves as a primary sensor of DNA damage, capable of detecting DNA breaks within 3 sec of their occurrence, and triggers the recruitment of repair complexes via the ADP-ribosylation of proteins near the damage site

Resistance to azoles is increasingly reported and involves several mechanisms: Overexpression of efflux pumps, including members of the ABC transporter superfamily and major facilitator superfamily (MFS)