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Notably, studies have established that exposure to hypobaric hypoxia promotes a redox imbalance, leading to an exacerbated increase in reactive oxygen species (ROS) along with deterioration of endogenous antioxidant defenses ( 2 O 2 ) in exhaled breath condensate (EBC), both at rest and during exercise at altitude, correlating with decreased arterial oxygen saturation and AMS symptom severity ( Based on these findings, various studies have proposed antioxidant use as a preventive therapeutic strategy, given that the only pharmacological treatment currently employed to mitigate AMS is acetazolamide, along with anti-inflammatory agents such as dexamethasone and ibuprofen

However, the signal communication between ferroptosis glioma cells and surrounding immune cells is not clear (76) ( Figure 2 )

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Studies conducted on flavonoids have shown that they may act as agonists and/or antagonists towards the activation of AhR transcription, thus constituting selective AhR modulators [62]